ROARABLE // PRO
GLOBAL DESKS // NYC --:--:-- NYSE
US TAPE
ROAR ▸

SYRE // Spyre Therapeutics Inc.

DES <GO> NASDAQ RQD COCKPIT → CIK 0001636282 ↗
Health Care • Biotechnology: Pharmaceutical Preparations
$96.56 ▼ -2.40 (-2.42%)
MKT CAP: $10.08B • VOL: 661.2K
SYRE // ROARABLE RATING & 5-PILLAR RQD CONFIDENCE 02:00 EST DETERMINISTIC ENGINE
PRIOR: RQD 55/100 [D+] (+0 PT) • UNCHANGED
ROARABLE D+
RQD CONFIDENCE
55 / 100 +0D
5 X 20-PT QUANT PILLARS
E 0 D 35 C 59 B 70 A 86+
Roarable Sell — Weak Fundamentals / Trim
01 MASSIVE / SEC XBRL
Forensic Fundamentals
[LOCKED] FLAGGED
UNLOCK BELOW TO REVEAL
02 INSTITUTIONAL TAPE & TREND
Whale & Options Flow
17 / 20
STRONG
52W RANGE 85% • VS 200D +30.2% • RSI 57.3
03 SEC XBRL CAPITAL ALLOCATION
Insider & Capital Conviction
[LOCKED] FLAGGED
UNLOCK BELOW TO REVEAL
04 FRED 90D r-MATRIX
Macro Regime Fit
11 / 20
NEUTRAL
NEUTRAL • r(10Y)=-0.03 (+19bp) • r(OAS)=-0.26
05 10-K REDLINE AUDIT
Forensic 10-K Risk
16 / 20
STRONG
20 BASE - 4 DEDUCT • 0 CRIT / 0 MED • STABLE
ALERT

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SYRE // CANDLESTICK & AUTO-TRENDLINE WORKSTATION6M: +39.68%⚡ TESTING RESISTANCE
2026-11-03O $98.96H $98.96L $96.56C $96.56VOL 661.2K
RES: $99.64SUP: $78.53SMA50: $89.54SMA200: $74.19
$115.7$92.87$70.05$47.23$24.41RES $99.64SUP $78.53$96.562026-05-042026-06-182026-08-052026-09-212026-11-03
SYRE // INSTITUTIONAL BULL VS. BEAR FORENSIC DEBATE
UNDERWEIGHT CONVICTION: 33/100
BEAR 0
100 BULL

Spyre Therapeutics Inc. (SYRE) exhibits 45.0% gross margins and -20.0% return on invested capital within Health Care (Biotechnology: Pharmaceutical Preparations), balanced against a 24.0x enterprise multiple and 4.8% implied options volatility.

▲ INSTITUTIONAL BULL THESIS (LONG)
01. Operating Leverage & Capital Efficiency Moat

Sustained 45.0% gross profitability converts into — operating margin and -20.0% ROIC, outpacing sector cost of capital.

ROIC: -20.0% // GM: 45.0%
02. Top-Line Expansion & Cash Conversion

YoY revenue trajectory of +17.6% paired with -1.64% free cash flow yield supports self-funded R&D and capital return.

REV YOY: +17.6% // FCF YLD: -1.64%
03. Balance Sheet Solvency & Forensic Quality

Altman Z-Score of 26.00 and Piotroski F-Score of 5/9 indicate low near-term refinancing stress.

ALTMAN Z: 26.00 // F-SCORE: 5/9
▼ INSTITUTIONAL BEAR THESIS (SHORT / RISK)
01. Multiple Compression & Duration Sensitivity

Trading at 24.0x trailing P/E (22.0x Fwd P/E) leaves valuation vulnerable if real 10Y TIPS yields spike.

P/E: 24.0x // EV/EBITDA: —
02. Options Skew & Event Volatility Risk

Options market prices a ±5.2% implied move with a 0.85 put/call ratio around $96.56 max pain.

IMPL MOVE: ±5.2% // P/C: 0.85
03. Competitive Margin & CapEx Cycle Pressure

Elevated industry capital intensity and customer concentration in Biotechnology: Pharmaceutical Preparations require continuous execution to defend — net margins.

NET MARGIN: — // D/E: 0.04x
KEY CATALYST // Upcoming 10-Q/10-K XBRL margin progression, guidance revision vs 22.0x forward consensus, and institutional 13F positioning.
MACRO REGIME // Monitor US 10Y Real Yields (DFII10) and High-Yield Credit Spreads (OAS) for beta-adjusted multiple impact (Beta 0.89).
FORM 4 & 13F FLOW OPEN OWN <GO>
FILER SIDE $ VALUE
INSPECT FULL OWNERSHIP LEDGER IN OWN <GO>
UNUSUAL OPTIONS TAPE OPEN OPT <GO>
STRIKE / EXP TYPE PREMIUM
INSPECT GEX & CHAIN IN OPT <GO>
KEY VALUATION & PROFITABILITY RATIOS XBRL FA <GO>
TRAILING P/E —
FORWARD P/E 22.0x
EV / EBITDA —
FCF YIELD -1.64%
GROSS MARGIN —
OPERATING MARGIN —
NET MARGIN —
ROIC % -20.0%
REV GROWTH YOY +17.6%
DILUTED EPS TTM $-1.49
DEBT / EQUITY 0.04x
DIVIDEND YIELD 0.00%
RSI-14 MOMENTUM 57.3
5Y EQUITY BETA 0.89
FRED MACRO SENSITIVITY (PEARSON r) ECST <GO>
MACRO CORRELATION CALIBRATION ACTIVE BELOW.
FRED MACRO REGIME STRESS-TEST SIMULATOR // SYREPEARSON R VARIANCE ENGINE
01 // SELECT FEDERAL RESERVE & CREDIT SHOCK SCENARIO
02 // POSITION NOTIONAL EXPOSURE
HEADLINE STRESS SCORE
75/100SEVERE DRAWDOWN PRESSURE
PRIMARY FACTOR EXPOSURE
DFII10 // -0.61 r
Latest: 2.08%
EST. DIRECTIONAL MOVE
-8.50%
Implied Px: $88.36
EST. DOLLAR VARIANCE
-$4,248
On $50,000 Notional
[LOCKED // MULTI-FACTOR DRAWDOWN HEDGE & MACRO TRIGGER ALERT]

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HEAD-TO-HEAD PEER COMPARISONS COMP <GO>