Yahoo Finance report covering Crescent Biopharma Inc. (CBIO) market action, institutional positioning, and fundamental catalysts.
Why CBIO Stock dropped -4.19% Today — RQD Quant Desk Flash
Crescent Biopharma Inc. (CBIO) carries a Roarable Rating of E (Strong Sell) with 29/100 RQD Confidence due to weak cash-flow efficiency and sensitivity to current interest rates. Wait for business cash flow and institutional buying to improve before committing fresh capital.
🤖 Mara Quenwick • AI Quant Lead (Click for Instant Brief)
Is CBIO stock a Buy, Hold, or Sell right now according to Roarable's RQD model?
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As of 2026-11-02, Crescent Biopharma Inc. (NASDAQ: CBIO) is rated E (Strong Sell / SELL) by Roarable's 5-pillar RQD engine with a composite confidence score of 29/100 at a spot price of $13.48 (-4.19% 1D, market cap $522.6M). Pillar breakdown: Fundamental Cash Engine 5/20, Institutional 13F & Options Flow 5/20, Executive Insider Alignment 13/20, FRED Macro Regime Fit 3/20, and SEC Balance-Sheet Forensics 3/20. Across 1016 tracked Health Care issuers, CBIO ranks #876 in composite RQD confidence.
🤖 Ellis Vennor • AI Peer & Flow Quant (Click for Instant Brief)
How does CBIO compare to ARVN and DMAC in the Health Care sector?
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Within the Health Care sector (Biotechnology: Pharmaceutical Preparations), CBIO carries a Roarable E (29/100 RQD), trailing P/E of N/A, gross margin of —, and ROIC of -35.0%. By comparison, ARVN (Arvinas Inc.) holds a E grade (23/100 RQD, P/E N/A, ROIC -32.1%, cap $516.6M) and DMAC (DiaMedica Therapeutics Inc.) posts a D grade (44/100 RQD, P/E N/A, ROIC -35.0%, cap $513.4M). Among the 5-stock peer group, CBIO leads on earnings multiple (N/A) while ARVN leads on capital efficiency (-32.1% ROIC).
🤖 Gideon Ashmere • AI SEC 10-K Forensics (Click for Instant Brief)
What are the biggest fundamental strengths and SEC risk factors for CBIO?
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Per CBIO's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001253689), Crescent Biopharma Inc. generated $10.8M in revenue, $153.9K in net income, and -$72.5M in free cash flow against $240.3M in total assets and $0 in total debt. Key quantitative strengths: Established market leader in Health Care with deep daily trading liquidity.. Primary risk factors monitored: Company executives have done more routine share selling than personal cash buying lately.. Institutional options positioning shows a 50% call / 50% put premium split.
Impersonal quantitative research (0–100 RQD rubric) — not individualized investment advice. Past performance does not guarantee future results. Full Disclaimer
Altman Z-Score 6.36 (FORTRESS SAFE (>3.0)) • Piotroski F-Score 3/9
SEC XBRL FY 2025 (10-K): 0% FCF Margin ($0 FCF) & 52% Gross Margin
Dilution Drag (+2.48% YoY Shares) & executive Form 4 sales trim 16 pts from alignment
⚔️ Adversarial Opposing Case: What Could Spark a CBIO Turnaround Squeeze
While CBIO currently carries a cautious 29/100 (E) rating due to Insider Conviction & Share Dilution (4/20), shorts face asymmetric squeeze risk if free cash flow inflects or management executes accretive buybacks.
Established market leader in Health Care with deep daily trading liquidity.
Options & Short-Covering Gamma: Reclaiming the 50-day SMA ($15.56) and Max Pain ($14.15) forces dealer call-delta covering toward $28.78.
Forensic Repair Trigger: Halting share dilution (Dilution Drag (+2.48% YoY Shares)) or retiring high-cost debt immediately upgrades the SEC 10-K Forensic pillar.
Why CBIO Stock dropped -4.19% Today — RQD Quant Desk Flash
Crescent Biopharma Inc. (CBIO) dropped -4.19% to $13.48, trading at 25% of its 52-week range ($8.72 – $27.41). Stretched risk/reward at current multiples (-35% return on capital) under elevated 10-year interest-rate pressure.
- ▸Technical Tape: Trading at 25% of its 52-week range ($8.72 – $27.41) with RSI-14 at 51.1 (NEUTRAL RANGE).
- ▸Volatility Profile: Historical 20-day realized swing band of ±12.5% around $13.48 (no active unusual options sweep snapshot on file).
- ▸Fundamental Anchor: Roarable E (Strong Sell) backed by 52% gross margin and $0 annual free cash flow.
TradingView report covering Crescent Biopharma Inc. (CBIO) market action, institutional positioning, and fundamental catalysts.
Investing.com report covering Crescent Biopharma Inc. (CBIO) market action, institutional positioning, and fundamental catalysts.
Stock Titan report covering Crescent Biopharma Inc. (CBIO) market action, institutional positioning, and fundamental catalysts.
Investing.com report covering Crescent Biopharma Inc. (CBIO) market action, institutional positioning, and fundamental catalysts.
TradingView report covering Crescent Biopharma Inc. (CBIO) market action, institutional positioning, and fundamental catalysts.
Stock Titan report covering Crescent Biopharma Inc. (CBIO) market action, institutional positioning, and fundamental catalysts.
https://www.dars.gov.et/ report covering Crescent Biopharma Inc. (CBIO) market action, institutional positioning, and fundamental catalysts.
WALTHAM, Mass., Nov. 02, 2026 (GLOBE NEWSWIRE) -- Crescent Biopharma, Inc. (“Crescent” or the “Company”) (Nasdaq: CBIO), a clinical-stage biotechnology company dedicated to rapidly advancing the next wave of therapies fo
HC Wainwright & Co. analyst Mitchell S. Kapoor reiterates Crescent Biopharma (NASDAQ:CBIO) with a Buy and maintains $36 price target.
Red-Light Warning Desk: Spotting SEC Cash-Flow & Dilution Risks Before Downgrades (Featuring CBIO)
- ✓Walkthrough of CBIO's RQD Radar, SEC cash-conversion gap & downside invalidation levels
- ✓3 asymmetric Bear/Hedge frameworks when 10-year Treasury yields stay elevated
- ✓Includes nightly RQD rating-change & forensic signal email alerts on your tracked stocks
CBIO Dilution Monitor, Expectations Hurdle, Butterfly Connections & Policy Exposure
Multi-year comparable XBRL diluted share count not disclosed (ETF or recent listing).
vs. +6.0% actual YoY revenue growth (assuming 9.25% cost of equity & 16.5x terminal multiple).
No active Ellis Vennor swing setup published on CBIO today. View full Setup Ledger →
No direct multi-tier Butterfly edges indexed yet for CBIO. Explore sector supply chains on /butterfly.
📊 Quantitative Sector Peer Comparison, SEC Filing Delta & Investment FAQ (CBIO)
1. Head-to-Head Health Care Peer Comparison (CBIO vs. ARVN, DMAC, INDP, OCS)
Industry: Biotechnology: Pharmaceutical Preparations (489 Tracked Issuers)Across 1016 tracked Health Care securities in the Roarable RQD universe, Crescent Biopharma Inc. (CBIO) ranks #876 by composite RQD confidence (29/100, grade E) and #439 by equity capitalization ($522.6M). Within this direct 5-issuer industry benchmark cohort, CBIO leads on earnings valuation at N/A trailing P/E, while ARVN leads on capital efficiency and profitability with -32.1% ROIC and — gross margin. OCS currently holds the highest overall quantitative score in the immediate peer group at 47/100 (D) compared with CBIO at 29/100 (E).
| Ticker / Company | Roarable Grade | RQD Score | Trailing P/E | Gross Margin | ROIC | 1D Change | Market Cap | Head-to-Head |
|---|---|---|---|---|---|---|---|---|
| CBIO
ACTIVE
Crescent Biopharma Inc. | E | 29/100 | — | — | -35.0% | -4.19% | $522.6M | Benchmark Subject |
| ARVN Arvinas Inc. | E | 23/100 | — | — | -32.1% | -0.51% | $516.6M | /arvn-vs-cbio → |
| DMAC DiaMedica Therapeutics Inc. | D | 44/100 | — | — | -35.0% | -2.84% | $513.4M | /dmac-vs-cbio → |
| INDP Indaptus Therapeutics Inc. | D | 44/100 | — | — | -35.0% | -7.48% | $513.0M | /indp-vs-cbio → |
| OCS Oculis Holding AG | D | 47/100 | — | — | — | +0.24% | $507.5M | /ocs-vs-cbio → |
2. Multi-Year SEC XBRL Revenue, Cash Flow & Balance-Sheet Trajectory (FY2023–FY2025)
SEC EDGAR 10-K • FILED 2025-12-31 • CIK 0001253689In its most recent audited fiscal period (FY2025, filed 2025-12-31), Crescent Biopharma Inc. (CBIO) reported GAAP revenue of $10.8M (N/A vs. FY2024 revenue of $0 ) , GAAP net income of $153.9K, operating cash flow of -$71.5M, and free cash flow of -$72.5M (-132.9% YoY). On the balance sheet, CBIO closed FY2025 with $240.3M in total assets against $0 in total debt (Altman Z-Score: 6.36, Piotroski F-Score: 3/9).
| Fiscal Period | Filing Date | Revenue | Net Income | Operating Cash Flow | Free Cash Flow | Total Assets | Total Debt |
|---|---|---|---|---|---|---|---|
| FY2025 (FY) | 2025-12-31 | $10.8M | $153.9K | -$71.5M | -$72.5M | $240.3M | — |
| FY2024 (FY) | 2024-12-31 | $0 | $37.9K | -$31.1M | -$31.1M | $35.6M | — |
| FY2023 (FY) | 2023-12-31 | $0 | $36.9K | -$34.9M | -$34.9M | — | — |
3. CBIO Data-Verified Investor FAQ (RQD Rating, Sector Peers, SEC Forensics & Technicals)
✓ SCHEMA.ORG FAQPAGE JSON-LD ENABLEDIs CBIO stock a Buy, Hold, or Sell right now according to Roarable's RQD model?
As of 2026-11-02, Crescent Biopharma Inc. (NASDAQ: CBIO) is rated E (Strong Sell / SELL) by Roarable's 5-pillar RQD engine with a composite confidence score of 29/100 at a spot price of $13.48 (-4.19% 1D, market cap $522.6M). Pillar breakdown: Fundamental Cash Engine 5/20, Institutional 13F & Options Flow 5/20, Executive Insider Alignment 13/20, FRED Macro Regime Fit 3/20, and SEC Balance-Sheet Forensics 3/20. Across 1016 tracked Health Care issuers, CBIO ranks #876 in composite RQD confidence.
How does CBIO compare to ARVN and DMAC in the Health Care sector?
Within the Health Care sector (Biotechnology: Pharmaceutical Preparations), CBIO carries a Roarable E (29/100 RQD), trailing P/E of N/A, gross margin of —, and ROIC of -35.0%. By comparison, ARVN (Arvinas Inc.) holds a E grade (23/100 RQD, P/E N/A, ROIC -32.1%, cap $516.6M) and DMAC (DiaMedica Therapeutics Inc.) posts a D grade (44/100 RQD, P/E N/A, ROIC -35.0%, cap $513.4M). Among the 5-stock peer group, CBIO leads on earnings multiple (N/A) while ARVN leads on capital efficiency (-32.1% ROIC).
What are the biggest fundamental strengths and SEC risk factors for CBIO?
Per CBIO's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001253689), Crescent Biopharma Inc. generated $10.8M in revenue, $153.9K in net income, and -$72.5M in free cash flow against $240.3M in total assets and $0 in total debt. Key quantitative strengths: Established market leader in Health Care with deep daily trading liquidity.. Primary risk factors monitored: Company executives have done more routine share selling than personal cash buying lately.. Institutional options positioning shows a 50% call / 50% put premium split.
Where is CBIO trading relative to its 50-day, 200-day, and 52-week technical levels?
CBIO last traded at $13.48 (-4.19% on volume of 189,524 shares), positioning the stock -13.37% below its 50-day simple moving average ($15.56) and -15.17% below its 200-day simple moving average ($15.89). Across its 52-week range of $8.72 to $27.41, CBIO sits at the 25.5% percentile with a 14-day RSI of 51.1 (NEUTRAL RANGE) and an implied next-earnings move of ±12.5% ($11.79 to $15.17).
CBIO Investor FAQ & Complete 8-Part Research Index
100% OPEN ACCESS • SEC EDGAR × CBOE × FREDWhy is CBIO stock moving today?
Why CBIO Stock dropped -4.19% Today — RQD Quant Desk Flash. Stretched risk/reward at current multiples (-35% return on capital) under elevated 10-year interest-rate pressure.
CBIO — Crescent Biopharma Inc.: What the Facts Mean to a Prospective Investor
Roarable Rating Brief: What This Means to a Prospective Investor
The Roarable RQD rating assigns a score of 29 out of 100, a letter grade of E, and a verdict label of "Roarable Strong Sell — Forensic Risk / Avoid." Per the Roarable RQD rating, the five pillars score as follows:
- Fundamental Cash Engine (5 / 20): Reflects an ROIC of -35% and an FCF yield of -13.86%. For a prospective investor, this indicates the business is not currently generating cash returns on invested capital, and free cash flow is negative relative to the market value.
- Whale 13F Flow (5 / 20): Covers institutional accumulation and options positioning. The source data does not provide the underlying 13F holdings detail, so the score can be read only as a weak institutional signal.
- Insider Conviction (3 / 20): Based on SEC Form 4 and Congressional PTR cluster flow. The low score signals limited evidence of insider conviction in the stock.
- Macro Regime Fit (3 / 20): Reflects a beta of 1.0 and sector sensitivity. A beta of 1.0 means the stock is expected to move in line with the broader market, offering no defensive cushion, while the low score signals weak alignment with the current macro regime.
- Forensic Balance Sheet (13 / 20): The strongest pillar, reflecting an Altman Z-Score of 6.36, a Piotroski F-Score of 3/9, and Debt/Equity of 0.5. The Altman figure points to a financially sturdier balance sheet than the cash-flow pillars, while the weak Piotroski score signals deteriorating fundamental quality.
Taken together, the pillar scores show that the balance sheet is the only area of relative strength; cash generation, institutional and insider signals, and macro fit all score poorly. For a prospective investor evaluating the stock today, the rating implies that upside depends on a turnaround in operating economics that the current data does not yet show, and that valuation cannot be anchored to earnings or cash flow because those measures are negative or unavailable. This is an analytical reading of the rating, not personalized financial advice.
Financial Trend
| Period | Revenue | Operating Income | Net Income | EPS | FCF | Cash | Debt |
|---|---|---|---|---|---|---|---|
| FY 2025 | $10.8M | $-152.6M | $0.2M | N/A | $-72.5M | $213.2M | N/A |
| FY 2024 | $0.0M | $-40.0M | $0.0M | N/A | $-31.1M | $34.8M | N/A |
| FY 2023 | $0.0M | $-39.3M | $0.0M | N/A | $-34.9M | N/A | N/A |
Per the SEC financials, operating margin is -60% and gross margin is 0%, while net margin is reported at 1.4% per the market data section, a figure that diverges sharply from the negative operating income and should be treated with caution. ROIC is -35% per the market data. The Roarable RQD rating cites an Altman Z-Score of 6.36, a Piotroski F-Score of 3/9, and Debt/Equity of 0.5, indicating a balance sheet with relatively low leverage but weak fundamental quality signals.
Recent Catalysts & News Wire Analysis
Per the recent news and catalysts section, the feed contains six items, all tagged with a YELLOW light and MARKET WIRE impact label:
- Inducement award grants announced (Yahoo Finance).
- Estimates coverage (TradingView).
- Stifel reiterated a Buy rating with a $28 target (Investing.com).
- A notice that three talks will be webcast live, with replays available for 90 days (Stock Titan).
- H.C. Wainwright reiterated a buy rating (Investing.com).
- H.C. Wainwright & Co. reiterated a Buy rating with a $36 price target (TradingView).
Key catalysts are the reiterated analyst Buy ratings and their stated price targets. Risk watch items include the negative operating income and free cash flow reported in the financials. Per the Butterfly Supply-Chain Graph, the supply chain is recorded as NONE, with no butterfly links and no proprietary signals.
Open Questions
- What is the path to positive operating income, given FY 2025 operating income of $-152.6M against revenue of $10.8M?
- Which specific revenue sources generated the FY 2025 revenue, and how durable are they?
- What explains the reported 1.4% net margin when operating income is deeply negative?
- What debt obligations sit behind the Debt/Equity figure, given that debt is reported as N/A in the financials?
- What is the consensus rating and price target distribution beyond the two reiterated ratings in the news feed?
CBIO Live News Feed, Press Releases & Catalyst Wire
Real-time company headlines, analyst actions, and sector developments for Crescent Biopharma Inc. (CBIO) • Click "Debate This Headline" to argue it in the Roar Pit below
Yahoo Finance report covering Crescent Biopharma Inc. (CBIO) market action, institutional positioning, and fundamental catalysts.
TradingView report covering Crescent Biopharma Inc. (CBIO) market action, institutional positioning, and fundamental catalysts.
Investing.com report covering Crescent Biopharma Inc. (CBIO) market action, institutional positioning, and fundamental catalysts.
Stock Titan report covering Crescent Biopharma Inc. (CBIO) market action, institutional positioning, and fundamental catalysts.
Investing.com report covering Crescent Biopharma Inc. (CBIO) market action, institutional positioning, and fundamental catalysts.
TradingView report covering Crescent Biopharma Inc. (CBIO) market action, institutional positioning, and fundamental catalysts.
Stock Titan report covering Crescent Biopharma Inc. (CBIO) market action, institutional positioning, and fundamental catalysts.
https://www.dars.gov.et/ report covering Crescent Biopharma Inc. (CBIO) market action, institutional positioning, and fundamental catalysts.
CBIO Bull vs. Bear Conversation Board — What's Your Call at $13.48?
🔥 Official Bull vs. Bear Debate: Is CBIO (E • RQD 29/100) a Buy at $14.07?
Welcome to the CBIO (Crescent Biopharma Inc.) Roar Pit. Current RQD Composite is 29/100 (Roarable Strong Sell — Forensic Risk / Avoid) in Biotechnology: Pharmaceutical Preparations. Bulls point to operating leverage and sector positioning, while bears focus on macro rate sensitivity and margin execution. Pick your side (🐂 Bull or 🐻 Bear) and drop your price target below.
Pump the brakes on CBIO — check the valuation vs. margin headwinds
Everyone in here is repeating the bull case on CBIO, but look at what you are paying: current EV/EBITDA multiples with tightening sector spreads. Unless Crescent Biopharma Inc. expands free cash flow yield next quarter, I would rather wait for a pullback closer to the 200-day moving average before touching this.
CBIO cash flow & RQD setup is being underpriced by the Street here
Looking at the 5-pillar RQD breakdown on CBIO, the market is fixating on short-term headline noise in Biotechnology: Pharmaceutical Preparations and ignoring the balance sheet and cash flow trajectory. At $14.07 (52-wk range $8.72 - $27.41), any beat on forward guidance forces shorts and underweight funds to chase.