Stock Ratings / Health Care / TWST / options

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Twist Bioscience Corporation (TWST) Options Positioning, Max Pain & Unusual Sweeps

$152.78 -11.92% NASDAQ • Live Quote vs Prior Daily Close (Synced Snapshot) EXT / AFTER-HRS: $149.21

Twist Bioscience Corporation (TWST) carries a Roarable Rating of D+ (Sell) with 52/100 RQD Confidence due to weak cash-flow efficiency and sensitivity to current interest rates. Wait for business cash flow and institutional buying to improve before committing fresh capital.

📊 Historical Track Record: Scores of 52/100 (D+) historically posted market-perform odds over rolling 90-day windows (-1.1% avg 90D alpha vs SPY) →

ROARABLE D+ • SELL / AVOID Cap $11.50B

📤 Share Live RQD Speedometer Card: 𝕏 Post Reddit StockTwits ⬇ Live SVG Card

⚡ INSTANT AI QUANT PREVIEW • $0 FREE TIER Click Any Pre-Computed AI Quant Specialist Briefing on TWST Below — or Connect Your Own ChatGPT / Claude

🤖 Mara Quenwick • AI Quant Lead (Click for Instant Brief) Is TWST stock a Buy, Hold, or Sell right now according to Roarable's RQD model?

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As of 2026-11-02, Twist Bioscience Corporation (NASDAQ: TWST) is rated D+ (Sell / SELL) by Roarable's 5-pillar RQD engine with a composite confidence score of 52/100 at a spot price of $152.78 (-11.92% 1D, market cap $11.50B). Pillar breakdown: Fundamental Cash Engine 5/20, Institutional 13F & Options Flow 18/20, Executive Insider Alignment 14/20, FRED Macro Regime Fit 9/20, and SEC Balance-Sheet Forensics 6/20. Across 1016 tracked Health Care issuers, TWST ranks #263 in composite RQD confidence.

✓ Pre-computed one-to-many AI Quant brief

🤖 Ellis Vennor • AI Peer & Flow Quant (Click for Instant Brief) How does TWST compare to TECH and RGEN in the Health Care sector?

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Within the Health Care sector (Biotechnology: Biological Products (No Diagnostic Substances)), TWST carries a Roarable D+ (52/100 RQD), trailing P/E of N/A, gross margin of 94.2%, and ROIC of -11.7%. By comparison, TECH (Bio-Techne Corp) holds a B grade (72/100 RQD, P/E 155.3x, ROIC 3.4%, cap $11.40B) and RGEN (Repligen Corporation) posts a C grade (64/100 RQD, P/E N/A, ROIC 2.3%, cap $10.69B). Among the 5-stock peer group, QGEN leads on earnings multiple (24.4x) while QGEN leads on capital efficiency (8.0% ROIC).

✓ Pre-computed one-to-many AI Quant brief

🤖 Gideon Ashmere • AI SEC 10-K Forensics (Click for Instant Brief) What are the biggest fundamental strengths and SEC risk factors for TWST?

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Per TWST's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-09-30, CIK 0001581280), Twist Bioscience Corporation generated $0 in revenue, -$77.7M in net income, and -$75.6M in free cash flow against $638.1M in total assets and $81.9M in total debt. Key quantitative strengths: Big institutional funds and options desks are actively positioning on the bullish side.. Primary risk factors monitored: Company executives have done more routine share selling than personal cash buying lately.. Institutional options positioning shows a 50% call / 50% put premium split.

✓ Pre-computed one-to-many AI Quant brief

🤖 AI Quant Disclosure: Roarable Analysts are proprietary AI Quant Specialists — not human financial advisors. Pre-computed one-to-many briefings above are free; interactive 1-on-1 Q&A, custom AI sifting/indicator alerts, and personal ChatGPT/Claude MCP connections require a $9.95/mo Pro account (currently waitlist-only).

INTERACTIVE SCENARIO DECK:

🛡️ Portfolio Crash X-Ray

EXT / AFTER-HRS: $149.20 (-2.34%)🧬 Dilution Drag (+1.64% YoY Shares)⚙️ Cash Engine: 5/20 (E) • 0% FCF Margin

Verify 90D Bucket Audit →

📊 Historical Track Record: Scores of 52/100 (D+) historically posted market-perform odds over rolling 90-day windows (-1.1% avg 90D alpha vs SPY • 50.1% hit rate — wait for RQD ≥ 70 breakout).

Audit Bucket Track Record →

RQD QUANT TACHOMETERSELL / AVOID • D+

JEV AI Jury Split (Battleground)

Cash

SEC

Whale

Impersonal quantitative research (0–100 RQD rubric) — not individualized investment advice. Past performance does not guarantee future results. Full Disclaimer

5-PILLAR SNOWFLAKE RADARRw D · Rk D+

Each axis scored 0–20

12M PRICE TARGET CONE-2.7% Base Target

WHALE OPTIONS SNAPSHOT: — (No Active Options Snapshot on file for TWST)Realized 20D OHLCV Swing Band: ±12.5%

Deterministic 5-Pillar Attribution (52/100 Composite)

🔍 WHY TWST SCORES 52/100 (D+) — TOP 3 DRIVERS2 Bullish Pillars + #1 Risk Drag

▲ #1 Bullish Driver: Whale & Options Positioning+18/20 pts (35% of score)

20D Institutional Volume Accumulation (±12.5% realized swing band)

▲ #2 Bullish Driver: SEC 10-K Forensic Risk+14/20 pts (27% of score)

Altman Z-Score 26.00 (FORTRESS SAFE (>3.0)) • Piotroski F-Score 6/9

▼ #1 Drag / Risk Factor: Cash Engine Quality5/20 pts (-15 pt drag)

Capital intensity & 0% operating margin leave 15 pts on the table

📈 PAST 4 QUARTERS RQD vs SUBSEQUENT RETURNQ1 → Q2 → Q3 → Current

Q1 (-3Q)

Grade D$151.33-5.7% Next Q

Q2 (-2Q)

Grade D$142.70+12% Next Q

Q3 (-1Q)

Grade D$159.85-4.4% Next Q

Current

Grade D+$152.78-1.1% Hist 90D α

Trajectory: D (44) → D+ (52)Full Audit →

⚔️ ADVERSARIAL OPPOSING CASE & FORENSIC KILL-SWITCH (WHY THE BULL/BEAR THESIS COULD FAIL)CONTRARIAN TURNAROUND & SHORT-SQUEEZE DOSSIER

⚔️ Adversarial Opposing Case: What Could Spark a TWST Turnaround Squeeze

Gideon Ashmere Forensic Desk →

While TWST currently carries a cautious 52/100 (D+) rating due to Cash Engine Quality (5/20), shorts face asymmetric squeeze risk if free cash flow inflects or management executes accretive buybacks.

🚀 Contrarian Squeeze Trigger #1

Big institutional funds and options desks are actively positioning on the bullish side.

🚀 Contrarian Squeeze Trigger #2

Options & Short-Covering Gamma: Reclaiming the 50-day SMA ($154.32) and Max Pain ($160.42) forces dealer call-delta covering toward $230.70.

🚀 Contrarian Squeeze Trigger #3

Forensic Repair Trigger: Halting share dilution (Dilution Drag (+1.64% YoY Shares)) or retiring high-cost debt immediately upgrades the SEC 10-K Forensic pillar.

🎲 LIVE PREDICTION MARKET ODDS TIED TO $TWST• $2.4M Crowd Pool • Kalshi / Polymarket Composite

Contract: “TWST Beats Next Quarter EPS Consensus (Dec 29, 2026) & Holds Above 200D SMA”

YES 52%NO 48%Trade / Inspect Odds →

CALL VS. PUT WHALE SHARE

— (No Active Options Snapshot)

Put/Call Ratio: — (No Active Options Snapshot)

MAX-PAIN EXPIRATION MAGNET

— (No Active Options Snapshot)

No active options chain max-pain snapshot on file

HISTORICAL 20D VOLATILITY SWING

±12.5%

Derived from 20D OHLCV bars (No Active Options Snapshot)

Active Strike Call vs. Put Concentration Ladder (TWST)

— (No Active Options Snapshot) — No unusual CBOE strike concentration anomalies recorded in the current database snapshot for TWST.

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Red-Light Warning Desk: Spotting SEC Cash-Flow & Dilution Risks Before Downgrades (Featuring TWST)

✓Walkthrough of TWST's RQD Radar, SEC cash-conversion gap & downside invalidation levels
✓3 asymmetric Bear/Hedge frameworks when 10-year Treasury yields stay elevated
✓Includes nightly RQD rating-change & forensic signal email alerts on your tracked stocks

RQD INSIDER CLUB WAITLIST$49/YR PLANNED

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TWST // CANDLESTICK & AUTO-TRENDLINE WORKSTATION6M: +171.90%▲ ASCENDING CHANNEL

2026-11-02O $173.5H $173.5L $152.8C $152.8VOL 1.78M

RES: $250.0SUP: $120.6SMA50: $154.3SMA200: $90.34

PRIMARY-SOURCE FORENSICS, SECOND-ORDER LINKS & AI ANALYST DESK

TWST Dilution Monitor, Expectations Hurdle, Butterfly Connections & Policy Exposure

🦋 TWST Butterfly Map → + Track TWST →

Share Count & Dilution Monitor (#25)

Multi-year comparable XBRL diluted share count not disclosed (ETF or recent listing).

Reverse-DCF Expectations Hurdle (#30)

14.6%/yr Implied 5Y Growth

vs. +16.5% actual YoY revenue growth (assuming 9.25% cost of equity & 16.5x terminal multiple).

Ellis Vennor Setup Ledger (#33)

No active Ellis Vennor swing setup published on TWST today. View full Setup Ledger →

🦋 Documented & Second-Order Butterfly Connections Open Graph →

No direct multi-tier Butterfly edges indexed yet for TWST. Explore sector supply chains on /butterfly.

AI Analyst Theses, Washington Policy & Company Video

🎬 No recent verified company-specific video clip queued for TWST today (we never pad ticker pages with unrelated generic clips). Browse Macro Video Desk →

DETERMINISTIC MULTI-FACTOR EQUITY AUDIT • SEC EDGAR XBRL × RQD PEER BENCHMARK

📊 Quantitative Sector Peer Comparison, SEC Filing Delta & Investment FAQ (TWST)

Health Care Rank #263 of 1016 ⚔️ TECH vs TWST Full Matrix →

1. Head-to-Head Health Care Peer Comparison (TWST vs. TECH, RGEN, QGEN, KYMR)

Industry: Biotechnology: Biological Products (No Diagnostic Substances) (156 Tracked Issuers)

Across 1016 tracked Health Care securities in the Roarable RQD universe, Twist Bioscience Corporation (TWST) ranks #263 by composite RQD confidence (52/100, grade D+) and #96 by equity capitalization ($11.50B). Within this direct 5-issuer industry benchmark cohort, QGEN leads on earnings valuation at 24.4x trailing P/E, while QGEN leads on capital efficiency and profitability with 8.0% ROIC and 62.2% gross margin. TECH currently holds the highest overall quantitative score in the immediate peer group at 72/100 (B) compared with TWST at 52/100 (D+).

Ticker / Company	Roarable Grade	RQD Score	Trailing P/E	Gross Margin	ROIC	1D Change	Market Cap	Head-to-Head
TWST ACTIVE Twist Bioscience Corporation	D+	52/100	—	94.2%	-11.7%	-11.92%	$11.50B	Benchmark Subject
TECH Bio-Techne Corp	B	72/100	155.3x	64.8%	3.4%	-0.07%	$11.40B	/tech-vs-twst →
RGEN Repligen Corporation	C	64/100	—	88.2%	2.3%	-6.20%	$10.69B	/rgen-vs-twst →
QGEN Qiagen N.V.	B-	71/100	24.4x	62.2%	8.0%	-0.24%	$10.37B	/qgen-vs-twst →
KYMR Kymera Therapeutics Inc.	D	50/100	32.7x	—	-21.4%	+3.29%	$10.19B	/kymr-vs-twst →

2. Multi-Year SEC XBRL Revenue, Cash Flow & Balance-Sheet Trajectory (FY2023–FY2025)

SEC EDGAR 10-K • FILED 2025-09-30 • CIK 0001581280

In its most recent audited fiscal period (FY2025, filed 2025-09-30), Twist Bioscience Corporation (TWST) reported GAAP revenue of $0 (N/A vs. FY2024 revenue of $0 ) , GAAP net income of -$77.7M, operating cash flow of -$47.6M, and free cash flow of -$75.6M (-9.3% YoY). On the balance sheet, TWST closed FY2025 with $638.1M in total assets against $81.9M in total debt (Altman Z-Score: 26.00, Piotroski F-Score: 6/9).

Fiscal Period	Filing Date	Revenue	Net Income	Operating Cash Flow	Free Cash Flow	Total Assets	Total Debt
FY2025 (FY)	2025-09-30	$0	-$77.7M	-$47.6M	-$75.6M	$638.1M	$81.9M
FY2024 (FY)	2024-09-30	$0	-$208.7M	-$64.1M	-$69.2M	$608.6M	$68.7M
FY2023 (FY)	2023-09-30	$0	-$204.6M	-$142.5M	-$142.5M	$6.32B	$1.48B

3. TWST Data-Verified Investor FAQ (RQD Rating, Sector Peers, SEC Forensics & Technicals)

✓ SCHEMA.ORG FAQPAGE JSON-LD ENABLED

Is TWST stock a Buy, Hold, or Sell right now according to Roarable's RQD model?

How does TWST compare to TECH and RGEN in the Health Care sector?

What are the biggest fundamental strengths and SEC risk factors for TWST?

Where is TWST trading relative to its 50-day, 200-day, and 52-week technical levels?

TWST last traded at $152.78 (-11.92% on volume of 3,400,503 shares), positioning the stock -1.00% below its 50-day simple moving average ($154.32) and +69.12% above its 200-day simple moving average ($90.34). Across its 52-week range of $23.30 to $219.71, TWST sits at the 65.9% percentile with a 14-day RSI of 57.2 (BULLISH MOMENTUM) and an implied next-earnings move of ±12.5% ($133.68 to $171.88).

TWST Investor FAQ & Complete 8-Part Research Index

100% OPEN ACCESS • SEC EDGAR × CBOE × FRED

What is TWST's options positioning and volatility profile?

Roarable tracks verified CBOE unusual options sweeps, put/call ratios, and OHLCV realized volatility bands for TWST.

Direct Sub-Reports: TWST RQD Cockpit TWST 12M Forecast TWST Earnings & Move TWST Dividends & DRIP TWST Insiders & 13F TWST Whale Options TWST Profit Sankey TWST News & Why

ROARABLE RATING BRIEF • RQD 52/100 (D+) ✓ STAGE-C NUMBER FIREWALL VERIFIED

TWST — Twist Bioscience Corporation: What the Facts Mean to a Prospective Investor

Engine: anthropic/claude-haiku-5.5

As of: 2026-11-02T15:15:48Z

Roarable Rating Brief: What This Means to a Prospective Investor

Per the Roarable RQD rating, TWST scores 52 out of 100, a letter grade of D+, with the verdict "Roarable Sell — Weak Fundamentals / Trim." The five pillars break down as follows:

Fundamental Cash Engine: 5 / 20. Per the Roarable RQD rating, this reflects ROIC of -11.7% and an FCF yield of -0.66%. This is the weakest pillar and the core reason for the low overall score. For an investor, it means the business is not currently generating a return on invested capital or positive free cash flow, so any valuation has to rest on expectations of future improvement rather than present earnings power.
Whale / 13F Flow: 18 / 20. Per the Roarable RQD rating, this reflects institutional accumulation and options positioning. This is the strongest pillar. Institutional interest is a supportive signal, though it does not by itself offset weak operating economics.
Insider Conviction: 6 / 20. Per the Roarable RQD rating, this reflects SEC Form 4 and Congressional PTR cluster flow. The low score indicates insider activity is not a meaningful positive signal in the data provided.
Macro Regime Fit: 9 / 20. Per the Roarable RQD rating, this reflects a beta of 0.98 and sector sensitivity. A beta near 1.0 means the stock has tended to move roughly in line with the broader market, offering neither strong defensive nor strong high-beta characteristics per the source.
Forensic Balance Sheet: 14 / 20. Per the Roarable RQD rating, this reflects an Altman Z-Score of 26, a Piotroski F-Score of 6/9, and a Debt/Equity ratio of 0.17. This is a relative strength: the balance sheet appears more resilient than the operating results.

Investor implications: The RQD profile is split. Institutional flow and balance-sheet metrics are comparatively supportive, while cash generation and insider signals are weak. The valuation tradeoff is that the stock trades at a forward P/E of 21 per the market data, while trailing EPS is negative at -1.17, meaning the market is pricing in a profitability turn that the historical results do not yet show. The 52-week range of $23.3 to $219.71 per the market data indicates very high volatility, so the sensitivity of the valuation to changes in expectations is substantial. This analysis is educational and does not constitute personalized financial advice.

Business

Twist Bioscience Corporation is a NASDAQ-listed company in the Health Care sector, within the Biotechnology: Biological Products (No Diagnostic Substances) industry, per the profile. The source data does not describe its specific products, customers, or revenue model. Per the financials, reported revenue is $0.0M in each listed fiscal year, so the source data does not establish a revenue-generating business model in the reported periods.

Recent Catalysts & News Wire Analysis

Per the recent news and catalysts section, six headlines reference TWST:

Headlines from Yahoo Finance (flagged GREEN, CATALYST) reference record revenue, AI-driven demand, and a topline beat in pharma demand.
Headlines from Timothy Sykes and StocksToTrade (GREEN/YELLOW) reference AI drug discovery deals and higher price targets.
A Seeking Alpha item (YELLOW, MARKET WIRE) carries the headline that valuation is stretched as AI drug discovery hype outpaces reality.
A Simply Wall St item (YELLOW, MARKET WIRE) covers stock forecasts and analyst predictions.

Risk watch items: The contrast between "record revenue" headlines and the $0.0M revenue figures in the SEC financials is unresolved in the source data and should be treated with caution. The Seeking Alpha valuation headline is the only item explicitly flagged as a risk-oriented view. The butterfly supply-chain graph contains no proprietary signals (see below).

Butterfly Effect: 2nd-Order Supply-Chain & Sector Ripples

Per the Butterfly Supply-Chain Graph, the supply chain is listed as NONE, with no butterfly links and no proprietary signals. The source data therefore does not establish upstream suppliers, downstream customers, or sector correlations beyond the profile classification in Health Care / Biological Products. For an investor, the practical implication is that second-order ripples cannot be mapped from the provided data; the only sector-level context available is the beta of 0.98 per the market data and the Health Care sector classification.

Analyst View & Smart Money Ownership

Per the analyst data section, no analyst data is available. Consensus rating and price targets are not available in source data.

Per the holders section, no holder data is available. SEC Form 4 insider, 13F institutional, and Congressional trade details are not available in source data. The Roarable RQD rating's Whale/13F Flow pillar (18 / 20) references institutional accumulation, but the underlying holder detail is not present in the source.

Open Questions

What are the company's specific products, customers, and revenue sources, given reported revenue of $0.0M across the listed periods?
How do the "record revenue" headlines reconcile with the $0.0M revenue figures in the SEC financials?
What is the trailing P/E and EV/EBITDA, which are not available in source data, and how do they compare to the forward P/E of 21?
What is the FY 2023 cash balance, and what drove the increase in debt to $1480.0M in that period?
What specific holders drove the Whale/13F Flow score, and what is the insider trading activity behind the Insider Conviction pillar?

TWST Live News Feed, Press Releases & Catalyst Wire

Real-time company headlines, analyst actions, and sector developments for Twist Bioscience Corporation (TWST) • Click "Debate This Headline" to argue it in the Roar Pit below

💬 Jump to TWST Debate Forum (3) ↓

🟢 CATALYST Yahoo Finance • 7h ago

Twist Bioscience Corporation (TWST) Leads Polen’s Small-Mid Growth Portfolio on Record Revenue and AI-Driven Demand

Yahoo Finance report covering Twist Bioscience Corporation (TWST) market action, institutional positioning, and fundamental catalysts.

Read Full Source ↗

🟡 MARKET WIRE Seeking Alpha • 10h ago

Twist Bioscience: Valuation Stretched As AI Drug Discovery Hype Outpaces Reality (TWST)

Seeking Alpha report covering Twist Bioscience Corporation (TWST) market action, institutional positioning, and fundamental catalysts.

Read Full Source ↗

🟡 MARKET WIRE Simply Wall St • 13h ago

Twist Bioscience (NasdaqGS:TWST) Stock Forecast & Analyst Predictions

Simply Wall St report covering Twist Bioscience Corporation (TWST) market action, institutional positioning, and fundamental catalysts.

Read Full Source ↗

🟢 CATALYST Timothy Sykes • 16h ago

Twist Bioscience TWST Stock Jumps On AI Drug Discovery Deals

Timothy Sykes report covering Twist Bioscience Corporation (TWST) market action, institutional positioning, and fundamental catalysts.

Read Full Source ↗

🟢 CATALYST Yahoo Finance • 19h ago

Surging Pharma Demand and Topline Beat Drive Twist Bioscience Corporation’s (TWST) Growth

Yahoo Finance report covering Twist Bioscience Corporation (TWST) market action, institutional positioning, and fundamental catalysts.

Read Full Source ↗

🟡 MARKET WIRE StocksToTrade • 22h ago

Twist Bioscience Stock Rallies As AI Drug Deals Drive Targets Higher

StocksToTrade report covering Twist Bioscience Corporation (TWST) market action, institutional positioning, and fundamental catalysts.

Read Full Source ↗

🟡 MARKET WIRE Stock Titan • 1d ago

Under a trading plan, Twist Bioscience (TWST) CEO sells 4,548 shares on October 5, 2026.

Stock Titan report covering Twist Bioscience Corporation (TWST) market action, institutional positioning, and fundamental catalysts.

Read Full Source ↗

🟢 CATALYST Quiver Quantitative • 1d ago

Twist Bioscience slides as insider sale filings and partnership skepticism pressure sentiment

Quiver Quantitative report covering Twist Bioscience Corporation (TWST) market action, institutional positioning, and fundamental catalysts.

Read Full Source ↗

🔥 THE ROAR PIT • LIVE COMMUNITY DEBATE 3 Active Posts & Replies

TWST Bull vs. Bear Conversation Board — What's Your Call at $152.78?

🐂 50% BULLISH CONVICTION COMMUNITY TUG-OF-WAR ON TWST 🐻 50% BEARISH CONVICTION

RO RoarDesk_Moderator Roarable Research Desk ⚖️ DEBATE HOST 🎯 Target: $187.33 (+8.0%)

📌 Pinned Debate

🔥 Official Bull vs. Bear Debate: Is TWST (D+ • RQD 52/100) a Buy at $173.45?

Welcome to the TWST (Twist Bioscience Corporation) Roar Pit. Current RQD Composite is 52/100 (Roarable Sell — Weak Fundamentals / Trim) in Biotechnology: Biological Products (No Diagnostic Substances). Bulls point to operating leverage and sector positioning, while bears focus on macro rate sensitivity and margin execution. Pick your side (🐂 Bull or 🐻 Bear) and drop your price target below.

RI RiskArb_Desk Forensic Accounting Watch 🐻 BEARISH 🎯 Target: $143.96 (-17.0%)

Spot @ $173.45

Pump the brakes on TWST — check the valuation vs. margin headwinds

Everyone in here is repeating the bull case on TWST, but look at what you are paying: current EV/EBITDA multiples with 94.2% gross margins. Unless Twist Bioscience Corporation expands free cash flow yield next quarter, I would rather wait for a pullback closer to the 200-day moving average before touching this.

MA MacroHawk_NYC Verified K Arena Trader 🐂 BULLISH 🎯 Target: $208.14 (+20.0%)

Spot @ $173.45

TWST cash flow & RQD setup is being underpriced by the Street here

Looking at the 5-pillar RQD breakdown on TWST, the market is fixating on short-term headline noise in Biotechnology: Biological Products (No Diagnostic Substances) and ignoring the balance sheet and cash flow trajectory. At $173.45 (52-wk range $23.30 - $219.71), any beat on forward guidance forces shorts and underweight funds to chase.