Yahoo Finance report covering Krystal Biotech Inc. (KRYS) market action, institutional positioning, and fundamental catalysts.
Why KRYS Stock surged +2.38% Today — RQD Quant Desk Flash
Krystal Biotech Inc. (KRYS) earns a Roarable Rating of B (Buy) with 72/100 RQD Confidence. High-quality cash engine (steady margins, 17% return on capital) with steady institutional support. The company’s underlying cash engine and institutional positioning keep the composite score in the Green Buy zone.
🤖 Mara Quenwick • AI Quant Lead (Click for Instant Brief)
Is KRYS stock a Buy, Hold, or Sell right now according to Roarable's RQD model?
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As of 2026-11-02, Krystal Biotech Inc. (NASDAQ: KRYS) is rated B (Buy / BUY) by Roarable's 5-pillar RQD engine with a composite confidence score of 72/100 at a spot price of $332.29 (+2.38% 1D, market cap $9.61B). Pillar breakdown: Fundamental Cash Engine 17/20, Institutional 13F & Options Flow 10/20, Executive Insider Alignment 18/20, FRED Macro Regime Fit 15/20, and SEC Balance-Sheet Forensics 12/20. Across 1016 tracked Health Care issuers, KRYS ranks #68 in composite RQD confidence.
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How does KRYS compare to PCVX and IBRX in the Health Care sector?
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Within the Health Care sector (Biotechnology: Biological Products (No Diagnostic Substances)), KRYS carries a Roarable B (72/100 RQD), trailing P/E of 46.9x, gross margin of —, and ROIC of 16.5%. By comparison, PCVX (Vaxcyte Inc.) holds a D grade (49/100 RQD, P/E N/A, ROIC -27.6%, cap $9.85B) and IBRX (ImmunityBio Inc.) posts a D- grade (37/100 RQD, P/E N/A, ROIC -27.3%, cap $9.26B). Among the 5-stock peer group, QGEN leads on earnings multiple (24.4x) while KRYS leads on capital efficiency (16.5% ROIC).
🤖 Gideon Ashmere • AI SEC 10-K Forensics (Click for Instant Brief)
What are the biggest fundamental strengths and SEC risk factors for KRYS?
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Per KRYS's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001711279), Krystal Biotech Inc. generated $389.1M in revenue (+33.9% YoY), $204.8M in net income, and $188.9M in free cash flow against $1.33B in total assets and $51.4M in total debt. Key quantitative strengths: Strong cash generator (steady margins)—profits are backed by real money, not accounting tricks.. Primary risk factors monitored: Priced at 47x earnings—high expectations leave less room for a lukewarm quarter.. Institutional options positioning shows a 50% call / 50% put premium split.
Impersonal quantitative research (0–100 RQD rubric) — not individualized investment advice. Past performance does not guarantee future results. Full Disclaimer
Altman Z-Score 26.00 (FORTRESS SAFE (>3.0)) • Piotroski F-Score 8/9
SEC XBRL FY 2025 (10-K): 48.5% FCF Margin ($188.9M FCF) & 52% Gross Margin
Put hedging (50% put share) caps near-term gamma upside (-10 pts vs max)
⚔️ Adversarial Opposing Case: Why the KRYS Bull Thesis Could Fail
Even with a 72/100 (B) score, KRYS faces multiple-compression risk if 46.9x trailing P/E re-rate toward historical sector medians or if hyperscaler/enterprise customer concentration slows in upcoming 10-Q filings.
Priced at 47x earnings—high expectations leave less room for a lukewarm quarter.
Dilution & Margin Drag: Disciplined Float (-0.04% YoY Shares) — any gross margin slip below 49.5% triggers an automatic RQD downgrade.
Technical & Forensic Kill-Switch: A daily close below the 50D SMA ($336.68) or 200D SMA ($308.94) invalidates the momentum regime and cuts Target Base ($353.22) toward Bear Floor ($272.48).
Why KRYS Stock surged +2.38% Today — RQD Quant Desk Flash
Krystal Biotech Inc. (KRYS) surged +2.38% to $332.29, trading at 75% of its 52-week range ($184.02 – $382.54). High-quality cash engine (steady margins, 17% return on capital) with steady institutional support.
- ▸Technical Tape: Trading at 75% of its 52-week range ($184.02 – $382.54) with RSI-14 at 48.2 (NEUTRAL RANGE).
- ▸Volatility Profile: Historical 20-day realized swing band of ±6.1% around $332.29 (no active unusual options sweep snapshot on file).
- ▸Fundamental Anchor: Roarable B (Buy) backed by 52% gross margin and $188.9M annual free cash flow.
Trefis report covering Krystal Biotech Inc. (KRYS) market action, institutional positioning, and fundamental catalysts.
StockInvest.us report covering Krystal Biotech Inc. (KRYS) market action, institutional positioning, and fundamental catalysts.
Seeking Alpha report covering Krystal Biotech Inc. (KRYS) market action, institutional positioning, and fundamental catalysts.
TradingView report covering Krystal Biotech Inc. (KRYS) market action, institutional positioning, and fundamental catalysts.
Yahoo Finance UK report covering Krystal Biotech Inc. (KRYS) market action, institutional positioning, and fundamental catalysts.
Benzinga report covering Krystal Biotech Inc. (KRYS) market action, institutional positioning, and fundamental catalysts.
富途牛牛 report covering Krystal Biotech Inc. (KRYS) market action, institutional positioning, and fundamental catalysts.
$127.3 million in 3Q VYJUVEK global revenue and $1.1 billion since launch VYJUVEK pricing negotiations in Germany and Italy completed KB113 clinical data demonstrate regression in more than 80% of assessed basal cell car
Krystal Biotech (NASDAQ:KRYS) reported third-quarter financial results on Monday. The transcript from the company’s third-quarter earnings call has been provided below.This transcript is brought to you by Benzinga APIs.
Scheduled RQD Strong Buys & Whale Accumulation Briefing (KRYS Tape Review)
- ✓Breakdown of the highest-scoring RQD Green-Light breakouts across our 5,200+ rated universe
- ✓Forensic Red-Light accounting & dilution traps to review on your watchlist
- ✓Includes downloadable .ics calendar invite & nightly RQD rating-change email alerts
KRYS Dilution Monitor, Expectations Hurdle, Butterfly Connections & Policy Exposure
Multi-year comparable XBRL diluted share count not disclosed (ETF or recent listing).
vs. +33.9% actual YoY revenue growth (assuming 9.25% cost of equity & 16.5x terminal multiple).
No active Ellis Vennor swing setup published on KRYS today. View full Setup Ledger →
No direct multi-tier Butterfly edges indexed yet for KRYS. Explore sector supply chains on /butterfly.
📊 Quantitative Sector Peer Comparison, SEC Filing Delta & Investment FAQ (KRYS)
1. Head-to-Head Health Care Peer Comparison (KRYS vs. PCVX, IBRX, KYMR, QGEN)
Industry: Biotechnology: Biological Products (No Diagnostic Substances) (156 Tracked Issuers)Across 1016 tracked Health Care securities in the Roarable RQD universe, Krystal Biotech Inc. (KRYS) ranks #68 by composite RQD confidence (72/100, grade B) and #117 by equity capitalization ($9.61B). Within this direct 5-issuer industry benchmark cohort, QGEN leads on earnings valuation at 24.4x trailing P/E, while KRYS leads on capital efficiency and profitability with 16.5% ROIC and — gross margin. KRYS currently leads its immediate peer cohort in composite quantitative strength at 72/100 (B).
| Ticker / Company | Roarable Grade | RQD Score | Trailing P/E | Gross Margin | ROIC | 1D Change | Market Cap | Head-to-Head |
|---|---|---|---|---|---|---|---|---|
| KRYS
ACTIVE
Krystal Biotech Inc. | B | 72/100 | 46.9x | — | 16.5% | +2.38% | $9.61B | Benchmark Subject |
| PCVX Vaxcyte Inc. | D | 49/100 | — | — | -27.6% | -0.93% | $9.85B | /pcvx-vs-krys → |
| IBRX ImmunityBio Inc. | D- | 37/100 | — | 96.0% | -27.3% | -5.15% | $9.26B | /ibrx-vs-krys → |
| KYMR Kymera Therapeutics Inc. | D | 50/100 | 32.7x | — | -21.4% | +3.29% | $10.19B | /kymr-vs-krys → |
| QGEN Qiagen N.V. | B- | 71/100 | 24.4x | 62.2% | 8.0% | -0.24% | $10.37B | /qgen-vs-krys → |
2. Multi-Year SEC XBRL Revenue, Cash Flow & Balance-Sheet Trajectory (FY2023–FY2025)
SEC EDGAR 10-K • FILED 2025-12-31 • CIK 0001711279In its most recent audited fiscal period (FY2025, filed 2025-12-31), Krystal Biotech Inc. (KRYS) reported GAAP revenue of $389.1M (+33.9% vs. FY2024 revenue of $290.5M , and +667.5% cumulative change since FY2023) , GAAP net income of $204.8M, operating cash flow of $200.9M, and free cash flow of $188.9M (+58.5% YoY). On the balance sheet, KRYS closed FY2025 with $1.33B in total assets against $51.4M in total debt (Altman Z-Score: 26.00, Piotroski F-Score: 8/9).
| Fiscal Period | Filing Date | Revenue | Net Income | Operating Cash Flow | Free Cash Flow | Total Assets | Total Debt |
|---|---|---|---|---|---|---|---|
| FY2025 (FY) | 2025-12-31 | $389.1M | $204.8M | $200.9M | $188.9M | $1.33B | $51.4M |
| FY2024 (FY) | 2024-12-31 | $290.5M | $89.2M | $123.4M | $119.2M | $1.06B | $49.3M |
| FY2023 (FY) | 2023-12-31 | $50.7M | $10.9M | -$88.8M | -$91.1M | $5.28B | $1.24B |
3. KRYS Data-Verified Investor FAQ (RQD Rating, Sector Peers, SEC Forensics & Technicals)
✓ SCHEMA.ORG FAQPAGE JSON-LD ENABLEDIs KRYS stock a Buy, Hold, or Sell right now according to Roarable's RQD model?
As of 2026-11-02, Krystal Biotech Inc. (NASDAQ: KRYS) is rated B (Buy / BUY) by Roarable's 5-pillar RQD engine with a composite confidence score of 72/100 at a spot price of $332.29 (+2.38% 1D, market cap $9.61B). Pillar breakdown: Fundamental Cash Engine 17/20, Institutional 13F & Options Flow 10/20, Executive Insider Alignment 18/20, FRED Macro Regime Fit 15/20, and SEC Balance-Sheet Forensics 12/20. Across 1016 tracked Health Care issuers, KRYS ranks #68 in composite RQD confidence.
How does KRYS compare to PCVX and IBRX in the Health Care sector?
Within the Health Care sector (Biotechnology: Biological Products (No Diagnostic Substances)), KRYS carries a Roarable B (72/100 RQD), trailing P/E of 46.9x, gross margin of —, and ROIC of 16.5%. By comparison, PCVX (Vaxcyte Inc.) holds a D grade (49/100 RQD, P/E N/A, ROIC -27.6%, cap $9.85B) and IBRX (ImmunityBio Inc.) posts a D- grade (37/100 RQD, P/E N/A, ROIC -27.3%, cap $9.26B). Among the 5-stock peer group, QGEN leads on earnings multiple (24.4x) while KRYS leads on capital efficiency (16.5% ROIC).
What are the biggest fundamental strengths and SEC risk factors for KRYS?
Per KRYS's SEC EDGAR XBRL 10-K filing (FY2025, filed 2025-12-31, CIK 0001711279), Krystal Biotech Inc. generated $389.1M in revenue (+33.9% YoY), $204.8M in net income, and $188.9M in free cash flow against $1.33B in total assets and $51.4M in total debt. Key quantitative strengths: Strong cash generator (steady margins)—profits are backed by real money, not accounting tricks.. Primary risk factors monitored: Priced at 47x earnings—high expectations leave less room for a lukewarm quarter.. Institutional options positioning shows a 50% call / 50% put premium split.
Where is KRYS trading relative to its 50-day, 200-day, and 52-week technical levels?
KRYS last traded at $332.29 (+2.38% on volume of 330,472 shares), positioning the stock -1.30% below its 50-day simple moving average ($336.68) and +7.56% above its 200-day simple moving average ($308.94). Across its 52-week range of $184.02 to $382.54, KRYS sits at the 74.7% percentile with a 14-day RSI of 48.2 (NEUTRAL RANGE) and an implied next-earnings move of ±6.1% ($312.02 to $352.56).
KRYS Investor FAQ & Complete 8-Part Research Index
100% OPEN ACCESS • SEC EDGAR × CBOE × FREDWhy is KRYS stock moving today?
Why KRYS Stock surged +2.38% Today — RQD Quant Desk Flash. High-quality cash engine (steady margins, 17% return on capital) with steady institutional support.
KRYS — Krystal Biotech Inc.: What the Facts Mean to a Prospective Investor
Roarable Rating Brief: What This Means to a Prospective Investor
The per the Roarable RQD rating, KRYS scores 72 out of 100, grading B, with the verdict "Roarable Buy — Good Risk/Reward." The five pillars are:
- Fundamental Cash Engine: 17 / 20. Per the Roarable RQD rating, this pillar reflects ROIC of 16.5% and an FCF yield of 1.97%. For an investor, this is the strongest evidence that the business converts capital into returns, though the low FCF yield means the market is paying a high price for each dollar of free cash flow.
- Whale 13F Flow: 10 / 20. Per the Roarable RQD rating, this pillar captures institutional accumulation and options positioning. The moderate score suggests institutional support is present but not dominant; no 13F detail is provided beyond the score.
- Insider Conviction: 12 / 20. Per the Roarable RQD rating, this pillar reflects SEC Form 4 and Congressional PTR cluster flow. A mid-range score indicates insider signals are neither a strong endorsement nor a warning.
- Macro Regime Fit: 15 / 20. Per the Roarable RQD rating, this pillar reflects beta of 0.91 and sector sensitivity. A beta below 1 implies the stock has historically moved less than the market, a defensive trait that benefits investors in volatile regimes but may lag in strong rallies.
- Forensic Balance Sheet: 18 / 20. Per the Roarable RQD rating, this pillar reflects Altman Z of 26, Piotroski F of 8/9, and Debt/Equity of 0.04. This is the strongest pillar and indicates low financial distress risk.
Valuation tradeoff: per the market data, the stock trades at a trailing P/E of 46.9 and an EV/EBITDA of 53.4, which the Roarable RQD rating does not separately penalize within its five pillars. An investor should weigh the strong forensic and cash-generation scores against the premium multiples and the 1.97% FCF yield when evaluating the stock today. This is an analytical framing, not personalized advice.
Snapshot
Financial Trend
| Period | Revenue | Operating Income | Net Income | EPS | FCF | Cash | Debt |
|---|---|---|---|---|---|---|---|
| FY 2025 | $389.1M | $161.3M | $204.8M | N/A | $188.9M | $496.3M | $51.4M |
| FY 2024 | $290.5M | $65.7M | $89.2M | N/A | $119.2M | $344.9M | $49.3M |
| FY 2023 | $50.7M | $-109.6M | $10.9M | N/A | $-91.1M | N/A | $1236.3M |
Per the SEC financials, revenue rose from $50.7M in FY 2023 to $389.1M in FY 2025, and operating income moved from $-109.6M to $161.3M over the same span. Per the market data, the operating margin is 41.5% and the net margin is 52.6%, with ROIC at 16.5%. Per the Roarable RQD rating, the Altman Z-Score is 26 and the Piotroski F-Score is 8/9. Per the SEC financials, debt fell from $1236.3M in FY 2023 to $51.4M in FY 2025, and the RQD rating reports Debt/Equity of 0.04. Gross margin is reported as 0% in the market data and should be treated as unreliable without further context.
Open Questions
- What are the company's specific products, approved indications, and revenue concentration, given the profile provides only sector and industry labels?
- What drove the move from $50.7M revenue in FY 2023 to $389.1M in FY 2025, and is that growth sustainable?
- Why is gross margin reported as 0%, and what is the true cost structure?
- Which institutions hold KRYS, and how have their positions changed over time?
- How do analysts value the stock relative to a 46.9 trailing P/E and 53.4 EV/EBITDA?
KRYS Live News Feed, Press Releases & Catalyst Wire
Real-time company headlines, analyst actions, and sector developments for Krystal Biotech Inc. (KRYS) • Click "Debate This Headline" to argue it in the Roar Pit below
Yahoo Finance report covering Krystal Biotech Inc. (KRYS) market action, institutional positioning, and fundamental catalysts.
Trefis report covering Krystal Biotech Inc. (KRYS) market action, institutional positioning, and fundamental catalysts.
StockInvest.us report covering Krystal Biotech Inc. (KRYS) market action, institutional positioning, and fundamental catalysts.
Seeking Alpha report covering Krystal Biotech Inc. (KRYS) market action, institutional positioning, and fundamental catalysts.
TradingView report covering Krystal Biotech Inc. (KRYS) market action, institutional positioning, and fundamental catalysts.
Yahoo Finance UK report covering Krystal Biotech Inc. (KRYS) market action, institutional positioning, and fundamental catalysts.
Benzinga report covering Krystal Biotech Inc. (KRYS) market action, institutional positioning, and fundamental catalysts.
富途牛牛 report covering Krystal Biotech Inc. (KRYS) market action, institutional positioning, and fundamental catalysts.
KRYS Bull vs. Bear Conversation Board — What's Your Call at $332.29?
🔥 Official Bull vs. Bear Debate: Is KRYS (B • RQD 72/100) a Buy at $324.55?
Welcome to the KRYS (Krystal Biotech Inc.) Roar Pit. Current RQD Composite is 72/100 (Roarable Buy — Good Risk/Reward) in Biotechnology: Biological Products (No Diagnostic Substances). Bulls point to capital efficiency (16.5% ROIC), while bears focus on valuation multiple compression (46.9x trailing P/E). Pick your side (🐂 Bull or 🐻 Bear) and drop your price target below.
Pump the brakes on KRYS — check the valuation vs. margin headwinds
Everyone in here is repeating the bull case on KRYS, but look at what you are paying: 46.9x trailing P/E with tightening sector spreads. Unless Krystal Biotech Inc. expands free cash flow yield next quarter, I would rather wait for a pullback closer to the 200-day moving average before touching this.
KRYS cash flow & RQD setup is being underpriced by the Street here
Looking at the 5-pillar RQD breakdown on KRYS, the market is fixating on short-term headline noise in Biotechnology: Biological Products (No Diagnostic Substances) and ignoring the balance sheet and cash flow trajectory. At $324.55 (52-wk range $184.02 - $382.54), any beat on forward guidance forces shorts and underweight funds to chase.